Modern understanding of vitamin D and the genetic regulation of inflammation in various clinical models

The concept of this literature review is based on the scientific hypothesis that inflammation, which basis various diseases, has common features, stages, pathophysiologically active substances control activity inflammatory reactions, and general genetic control. In review, individual diseases are grouped into several models leading pathogenetic mechanisms inflammation: autoimmune, microbial, lymphoproliferative, metabolic, allergic. connection with importance 25(OH) D for human health, its role in pathogenesis a number diversity functions complexity metabolism due to polymorphism regulatory genes, one hand, it seems very important monitor supply biologically effector population groups, as well as, timely detection insufficient need additional intake vitamin D, switching targeted therapy if necessary, other study certain features molecular influence course outcome pathophysiological inflammation.